When I started RVing I had that thought of renting rather than towing. It didn't take more than a couple of long trip without a toad to discover that, although rental cars are available near most airports served by the airlines and in some other places, the places that we went were rarely such places -- hotel living might be more appropriate for those places where you can rent a car, since the bigger the city (generally speaking) the less likely you'll find camping areas convenient for your intended destination.
Example -- we went to Quartzsite, AZ our first January, and we'd have probably had to rent a car in Phoenix, over 100 miles away.
Example -- We went to visit our son in Baltimore, and it was almost a 30 minute drive from the most convenient camping area (near the PA border) to his house, which is on the north side of the metro area.
Example -- we went on a much shorter outing to Golden Gate Canyon State Park in CO (we live near Denver), and we'd have needed to rent in Denver and have DW follow me in the motorhome with that rental.
Think of the types of places you might go and check for campgrounds and car rentals within reasonable distances.
These two sites can help you find campgrounds of any type anywhere in the U.S.:
Contact us today for full details and contact info in the Allstays.com complete guide to campgrounds, RV parks and parking lots for boondocking, hotels, motels, and much, much more.
www.allstays.com
Directory and reviews of RV Parks, Rest Areas, and other RV friendly places in the U.S. and Canada.
www.rvparky.com
So much depends on you...